Coley's toxin: historical perspective.
نویسندگان
چکیده
منابع مشابه
Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley's Toxin
Several decades after Coley's initial work, we here systematically analyzed tumoricidal as well as immunostimulatory effects of the historical preparation Coley's Toxin (CT), a safe vaccine made of heat-inactivated S. pyogenes and S. marcescens. First, by performing in vitro analysis, established human pancreatic carcinoma cell lines responded with dose- and time-dependent growth inhibition. Ef...
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Purpose: Mixed bacterial vaccine (MBV, Coley’s toxins) is a historical, vaguely defined preparation of heat-inactivated Streptococcus pyogenes and Serratia marcescens used as nonspecific immunotherapy in the treatment of cancer. The mechanism of action is suspected to have an immunologic basis, yet it is poorly defined up to now. We developed a new, biochemically well defined and current good m...
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Spontaneous tumors regression has been associated with microbial infection for 100s of years and inspired the use of bacteria for anticancer therapy. Dr. William B. Coley (1862-1936), a bone- sarcoma surgeon, was a pioneer in treating his patients with both live bacterial-based and mixture of heat-killed bacteria known as "Coley's toxins." Unfortunately, Coley was forced to stop his work which ...
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Preliminary reports of these investigations by Diller and Shear (9) and Diller (8) indicated in a general way the degenerative responses of tumor cells to a polysaccharide derived by Shear and his associates (18) from Serrat ia marcescens culture filtrate. The present paper comprises the detailed account of these cellular changes. The use of bacterial toxins in tumor therapy was reviewed by She...
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Some strains of Clostridium perfringens, Clostridium spiroforme and Clostridium difficile produce binary toxins known respectively as iota toxin, S toxin and CDT. Each toxin consists of two unlinked polypeptides (e.g. CDTa and CDTb) that only together have biological activity. Taking an historical perspective, we review the development and early use of assays employing the specific neutralizati...
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ورودعنوان ژورنال:
- The Israel Medical Association journal : IMAJ
دوره 4 6 شماره
صفحات -
تاریخ انتشار 2002